Figure 6.

Schematic of paclitaxel prodrug (Pro) and lapatinib (LAP) co-loaded nanoparticle formulation with Flash NanoPrecipitation (FNP). The drugs are encapsulated by in situ tannic acid (TA) and iron coordination complex using an amphiphilic block copolymer stabilizer, polystyrene-b-polyethylene glycol (PS-b-PEG). The organic stream containing PS-b-PEG, TA, prodrug, and lapatinib, is rapidly mixed with Fe³⁺ in a confined impinging jet (CIJ) mixer. The resulting nanostructures are 145 ± 2 nm in diameter.