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The half maximal inhibitory concentration (IC50) of free paclitaxel (PTX), free paclitaxel prodrug (Pro), prodrug nanoparticles (Pro NPs), and prodrug-lapatinib nanoparticles Pro-LAP NPs compared to paclitaxel-loaded nanoparticles (PTX NPs) in ovarian cancer cell line OVCA-432.
| Drug Treatment | IC50 (μM) | |
|---|---|---|
| Free PTX | 83 ± 6 | |
| Free Prodrug | 10 ± 5 | |
| PTX NPs | 0.047 ± 0.004 | |
| Pro NPs | 0.009 ± 0.002 | |
| Pro-LAP NPs: | Prodrug | 0.00442 ± 0.00001 |
| LAP | 0.00740 ± 0.00002 | |
