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. 2020 Dec 3;21(23):9245. doi: 10.3390/ijms21239245

Figure 2.

Figure 2

FABP4 inhibition suppressed the oxidized-LDL-induced adhesiveness of MNCs by modulating the adhesion molecules. Oxidized-LDL enhanced the FABP4 expression in MNCs from control subjects (A). The oxidized-LDL (50 µg/mL)-induced adhesiveness of MNCs was reversed by FABP4 neutralizing antibody (B). The expression of adhesion molecules, such as intergrin β2, integrin α4, and P-selectin glycoprotein ligand 1 (PSGL-1), was higher in MNCs from CAD patients (C). The oxidized-LDL-induced adhesiveness of MNCs was reversed by integrin β2, integrin α4, and PSGL-1 neutralizing antibodies (D). FABP4 neutralizing antibody reduced the oxidized-LDL-induced integrin β2, integrin α4, and PSGL-1 expression in MNCs (E). N represents normal subjects; Pt represents CAD patients; B represents baseline. N = 6 in each experiment. Data are presented as means ± standard errors. Statistical analyses were performed using Student’s t test. Data were considered statistically significant when the p-value was <0.05. * p < 0.05, # p < 0.01.