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. 2020 Dec 2;21(23):9201. doi: 10.3390/ijms21239201

Figure 3.

Figure 3

Effects of LGF in tau pathology, ubiquitinated protein levels and HSP70 heat shock protein expression. Panel (A), shows the relative optical density of phospho-tau/tau ratio analyzed by Western blot and expressed as % vs. WT. Note how LGF treatment reduces the expression of phosphorylated tau in the hippocampus and cerebral cortex in APP mice. Panels (B,C) show the quantification of accumulated ubiquitinated proteins (B) and HSP-70 (C) in the hippocampus and cerebral cortex of APPswe mice. Note how LGF reduces the accumulation of ubiquitinated proteins (B) and increases HSP70 expression (C). Panel (D) shows representative Western blot images of phospho-tau, total tau, Hsp-70 and β-actin as charge control. Results represent the mean ± SEM of 4 to 8 independent mice. The statistical analysis was performed by one-way ANOVA followed by Newman–Keuls test. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 vs. WT. + p ≤ 0.05, ++ p ≤ 0.01, +++ p ≤ 0.001 vs. APPswe mice.