Figure 6.

Effect of LGF on the expression of proteins involved in cell survival. Protein expression was analyzed by Western blot using specific antibodies against Bcl2, Bax, p-Akt and Akt. Panel (A), shows that LGF increases Bcl-2/Bax ratio in the hippocampus. This effect is mainly due to a reduction in Bax protein levels (B). Panels (C,D) show that phospho-Akt/Akt ratio (C) and phospho-Akt protein levels (D) are significantly increased in the hippocampus of APP and APP-LGF treated mice. Results represent the mean ± SEM of 4 to 8 independent mice. The statistical analysis was performed by one-way ANOVA followed by Newman–Keuls test. * p ≤ 0.05, ** p ≤ 0.01, vs. WT.+ p ≤ 0.05, ++ p ≤ 0.01 vs. APPswe mice.