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T cell development and maturation. T cells originate from hematopoietic stem cells in the bone marrow. These cells then migrate to thymus where they first develop into double-negative thymocytes (DN1-DN4). These thymocytes can be differentiated based on CD117, CD44, CD25, CD3, and CD 127 markers. DN4 then differentiates into double-positive (DP, CD4+CD8+) thymocytes after pre-TCR signaling. These DP’s differentiate into single-positive thymocytes as CD4+ and CD8+ cells.
