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. 2020 Dec 10;10:21683. doi: 10.1038/s41598-020-77760-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The distribution of RGC nucleus area changes over the course of the OHT (A, C) and pONT (B, D) models. (A) Average RGC nucleus area does not significantly change over the course of the OHT model. (B) However, a significant increase in nuclear area is observed 3 days after pONT induction, followed by a reduction in area from 7 days post pONT (One-way ANOVA, Tukey post-hoc test, *p < 0.05, ***p < 0.001). Data points represent individual animals, to illustrate inter-animal variability. (C, D) Overall, the RGC density declines and the distribution of RGC density by nucleus area shifts to the right over the course of the (C) OHT model and (D) pONT models, although this trend is more subtle in the OHT model.