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. 2020 Dec 6;21(23):9300. doi: 10.3390/ijms21239300
α-MSH alpha-melanocyte-stimulating hormone
ACTH adrenocorticotropic hormone
Ad-MAGEA3 adenovirus vaccine expressing melanoma-associated antigen 3
AEs adverse events
AK actinic keratoses
allo-HCT allogeneic hematopoietic stem cell transplantation
ASIP agouti signaling protein
BCC basal cell carcinoma
BID twice daily
CI confidence interval
CM cutaneous melanoma
CR complete response
cSCC cutaneous squamous cell carcinoma
CTCL cutaneous T cell lymphoma
CTL cytotoxic T lymphocyte
DCR disease control rate
DoR duration of response
EAP expanded access program
EGFR epidermal growth factor receptor
EMA European Medicines Agency
FDA U.S. Food and Drug Administration
FGF fibroblast growth factor
GVHD graft-versus-host disease
Gy Gray
HGF hepatocyte growth factor
HNSCC head and neck squamous cell carcinoma
i.m. intramuscular
i.t. intratumoral
i.v. intravenous
ICB immune checkpoint blockade
laSCC locally advanced cSCC
MC1R melanocortin 1 receptor
MG1-MAGEA3 MG1 Maraba oncolytic virus expressing melanoma-associated antigen 3
mSCC metastatic cSCC
NER nucleotide excision repair
NMSC non-melanoma skin cancer
NSCLC non-small cell lung cancer
ORR objective response rate
OS overall survival
OTR organ transplant recipient
PD progressive disease
PFS progression-free survival
PR partial response
POMC proopiomelanocortin
PYs person-years
Q2W every 2 weeks
Q3W every 3 weeks
Q4W every 4 weeks
Q6W every 6 weeks
QD daily
QoL quality of life
QW every week
RCT randomized-controlled trial
RFS recurrence free survival
rhIL-7-hyFc recombinant human interleukin-7 and hybrid Fc fusion protein
RP1 genetically modified herpes simplex virus 1
RR response rate
SCF stem cell factor
SD stable disease
T-VEC talimogene laherparepvec
XP xeroderma pigmentosum