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Synthesis of 2-amino-3-chloropyridin 2-substituted-1,2-thiazinane-6-carboxamide-1,1-dioxides 22a–c. (a) THF, Et3N, 0 °C, then at rt 1 h; (b) 1-bromo-3-chloropropane, K2CO3, DMF; (c) NaOH, MeOH/H2O, 3 h; (d) EDC, HCl, DMAP; (e) ethyl acetate/CH3CN/H2O (2:2:1), PhI(OAc)2, rt, 2 h.
