Scheme 69.
Synthesis of oxadiazolyl-1,3-thiazinane-4-carboxylic acid 217. (a) KF, 2-(dicyclohexylphosphino)-2′-methylbiphenyl, pd(OAc)2, toluene, 70 °C, 12 h; (b) DMSO/H2O, Phosphate buffer, pH 7.4.
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