ATP	adenosine triphosphate
AUC	area under the curve
B2pin2	Bis(pinacolato)diboron
BLK	B-lymphoid tyrosine kinase
BMX/ETK	bone marrow tyrosine kinase on chromosome X
br s	broad singlet
BRET	bioluminescence resonance energy transfer
BTK	Bruton’s tyrosine kinase
CDI	1,1′carbonyldiimidazole
DAD	diode array detector
DCM	dichloromethane
DMEM	Dulbecco’s modified Eagle’s medium
DMF	N, N-dimethylformamide
DMSO	dimethyl sulfoxide
EC50	half maximal effective concentration
EGFR	epidermal growth factor receptor
ESI	electron spray ionization
Et3N	triethylamine
EtOAc	ethyl acetate
EtOH	ethanol
GSH	glutathione
HER	human epidermal growth factor receptor
HPLC	high performance liquid chromatography
IC50	half maximal inhibitory concentration
ITK	interleukin-2-inducible T-cell kinase
JAK	Janus kinase
KOAc	potassium acetate
LC	liquid chromatography
MAP2K7/MKK7	mitogen activated protein kinase kinase 7
MeOH	methanol
MES	2-(N-morpholino)ethanesulfonic acid
MS	mass spectrometry
NaH	sodium hydride
n-BuLi	n-Butyllithium
NBS	N-bromosuccinimide
NMR	nuclear magnetic resonance spectroscopy
Pd/C	palladium on activated carbon
Pd(OAc)2	palladium(II)acetate
PEG	polyethylene glycol
PH	pleckstrin homology
rt	room temperature
SAR	structure–activity relationship
sat.	saturated
SEM	2-(trimethylsilyl)ethoxymethyl
tBuOH	tert-Butanol
tBu3P Pd G3	Mesyl[(tri-t-butylphosphine)-2-(2-aminobiphenyl)]palladium(II)
TCEP	tris(2-carboxyethyl)phosphine
∆Tm	thermal shift
tret	retention time
TEC	tyrosine kinase expressed in hepatocellular carcinoma
TFA	trifluoroacetic acid
TH	TEC homology
THF	tetrahydrofurane
TLC	thin layer chromatography
TMS	tetramethylsilane
TOF	time of flight
Tris	tris(hydroxymethyl)aminomethan
TsCl	tosyl chloride
TSK/EMT	interleukin-2-inducible T-cell kinase
TXK/RLK	tyrosine-protein kinase
UV	ultraviolet
XLA	X-linked agammaglobulinemia
XPhos	2-Dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl
XPhos Pd G3	(2-Dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate
XPhos Pd G4	(2-Dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-N-methylamino-1,1′-biphenyl)]palladium(II) methanesulfonate