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. 2020 Dec 5;21(23):9295. doi: 10.3390/ijms21239295

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Basal cell carcinoma (BCC)-like tumors of 7,12-Dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-treated Ptch^f/f CD4Cre skin appear exclusively IFE-associated. (A) Experimental set-up of the DMBA/TPA carcinogenesis protocol. (B–E) Representative hematoxylin and eosin (H&E) stainings (B,D) and anti-K5 antibody stainings (C,E) of BCC from 42-week-old DMBA/TPA-treated Ptch^f/f CD4Cre (B,C) and Ptch^+/− back skin (D,E) (N_{Ptchf/f CD4Cre} = 13 and N_Ptch+/− = 8). Solid arrows: BCC associated to the IFE; open arrows: BCC associated to HF. HF: hair follicle, SG: sebaceous gland. Boxes: zoomed areas. Scale bars: 20 µm (B, left and D, left) and 100 µm (B, right, C and D, right and E).