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. 2020 Dec 7;21(23):9321. doi: 10.3390/ijms21239321

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Structural formula of CC-115 and dose escalation study. (A) Chemical structural formula of CC-115 (C16H16N8O) [54] (B) Healthy donor skin fibroblasts (SBLF7) and patient derived melanoma cells (ARPA, HV18MK) were treated for 48 h in a dose escalation study with 0.1–25 µmol/L CC-115. Dead cells were defined as sum of apoptotic and necrotic cells measured using flow cytometry (apoptosis/necrosis analysis by Annexin V-APC/7-AAD staining). Half maximal inhibitory concentrations (IC50) for the different cell line are displayed. Each value represents mean ± SD.