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. 2020 Nov 26;21(23):8993. doi: 10.3390/ijms21238993

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The immune interaction and metabolic character of tumor cells and the mechanism of immune checkpoint inhibitor and metabolic intervention. APC: antigen-presenting cell; α-KG: α-Ketoglutaric acid; GLUT1: glucose transporter 1; HIF1α: hypoxia-inducible factor 1α; SIRT6: Sirtuin 6; TCA cycle: tricarboxylic acid cycle; GLS1: glutaminase; GDH: glutamate dehydrogenase; LDHA: lactate dehydrogenase A; PD-1: program death 1; PDL-1: program death ligand 1; TCR: T cell receptor; MHC: major histocompatibility complex.