Skip to main content
. 2020 Dec 3;25(23):5714. doi: 10.3390/molecules25235714

Figure 2.

Figure 2

TAp63α acts as the central integrator for DNA damage signaling in oocytes. Detection of either double-strand breaks or single-strand breaks activates the ATM/CHK2 or the ATR/CHK1 pathway, respectively. Phosphorylation of TAp63α on S582 by CHK2 or CHK1 recruits a second kinase, CK1, which adds four more phosphates. This leads to opening of the closed dimeric state. In its active tetrameric conformation, TAp63α acts as a transcriptional activator resulting in the expression of PUMA and NOXA which, in turn, activate Bax.