Table 1.

Effects of acute treatment with crocins and flumazenil on rats’ performance in the open field test (n = 8 rats per group).

Treatment	Number of Squares Crossed	Number of Rearings	Time Spent in the Central Zone (s.)	Grooming Duration (s.)
Vehicle + vehicle	96 ± 5.5	29.4 ± 4	7.8 ± 2.3	10.8 ± 2.1
Flumazenil (10 mg/kg) + vehicle	107.3 ± 6.3	32 ± 1.4	9.3 ± 2.1	9.4 ± 1.7
Crocins (50 mg/kg) + vehicle	94.4 ± 4	29 ± 1.5	21.1 ± 1.7 *	7.8 ± 0.8
Flumazenzil + crocins	99.6 ± 4.9	32.8 ± 2.5	8.5 ± 0.7	9.9 ± 0.5

Crocins and flumazenil were injected intraperitoneally 60 or 30 min before testing respectively. The values are mean ± SEM. * p < 0.05 vs. all the other groups.