Figure 1.

(A) Primary sequence of TAR DNA-binding protein 43 (TDP-43). The fragments of 102–269 (RRMs) and 256–264 (ALR) discussed in this study overlined and underlined respectively. The amino acids, which are able to chelate Zn²⁺ ions are highlighted: in clear blue—Glu, in green—Cys and in grey—His. (B) Domain organization of TDP-43: NTD—N-terminal domain; NLS—nuclear localization sequence; RRM1 and RRM2—RNA-recognition domains; NES—nuclear export signal. ALR in TDP-43 and Aβ₄₀ sequence highlighted in yellow, amino acids that chelate Zn²⁺ in Aβ₄₀ are underlined.