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. 2020 Nov 26;21(23):8998. doi: 10.3390/ijms21238998

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Double immunofluorescence with combinations of CD68/CCR2 (A) and CD163/CCR2 (B) on day 2, and mRNA expressions for CCR2 (C) and CCL7 (D) in APAP-induced rat hepatotoxicity. Almost all CD68 positive macrophages label CCR2 (A) (close to 100%), whereas double-positive cells with CCR2/CD163 were very few (B) (less than 10%). Yellow color (arrows) indicates double-positive reactions. Blue is nucleus stained with 4’,6-diamino-2-phenylindole (DAPI). mRNA expression levels of CCR2 (C) and CCL7 (D), normalized by the expression levels of 18s RNA, are significantly increased on days 1 and 2. Dunnett’s test; *, significantly different from controls at p < 0.05. Bar represents the mean ± SD. CV, central vein. Bar = 40 µm.