Table 1.
Comparison of the biodistribution of [99mTc]Tc-CNGU and other 99mTc-labeled glutamate-urea-based PSMA-targeted inhibitors.
| Complex |
[99mTc]Tc- CNGU |
99mTc-MIP-1404 |
99mTc-EDDA/HYNIC- iPSMA |
99mTc-HYNIC- ALUG |
[99mTc]Tc-16 |
|---|---|---|---|---|---|
| Cell | LNCaP | LNCaP | LNCaP | LNCaP | 22Rv1 |
| Animal | BALB/c | NCr nude | Athymic mice | SCID | BALB/c |
| Tumor | 4.86 ± 1.19 | 10.3 ± 2.5 | 10.22 ± 2.96 | 14.13 ± 2.95 | 1.87 ± 0.11 |
| Kidneys | 70.95 ± 12.28 | 105 ± 37 | 23.63 ± 3.56 | 197.50 ± 7.1 | 24.66 ± 2.17 |
| T/B | 2.89 | 79 | 62.33 | 11.78 | 4.43 ± 0.39 |
| T/M | 12.46 | 57 | 68.13 | 19.45 | 14.05 ± 1.78 |
| log P | −1.97 ± 0.03 | -- | -- | −2.68 ± 0.12 | −2.10 ± 0.03 |
| Reference | This study | [26] | [24] | [22] | [30] |
T/B: Tumor/Blood; T/M: Tumor/Muscle. Radioactive accumulation in each organ or tissue is expressed as % ID/g. --: The data was not mentioned in the original literatures.