Table 2.
Biodistribution of [99mTc]Tc-CNGU in BALB/c male nude mice bearing LNCaP (PSMA+) tumor 1 h post-injection.
| Organs | 1 h | 1 h Blockade |
|---|---|---|
| Heart | 0.74 ± 0.15 | 0.46 ± 0.04 |
| Liver | 2.46 ± 0.72 | 1.48 ± 0.16 |
| Spleen | 5.84 ± 1.51 | 0.78 ± 0.19 * |
| Lung | 1.89 ± 0.30 | 1.47 ± 0.19 |
| Kidneys | 70.95 ± 12.28 | 19.85 ± 1.30 * |
| Stomach | 0.64 ± 0.21 | 0.44 ± 0.14 |
| Bone | 0.43 ± 0.11 | 0.40 ± 0.08 |
| Intestine | 2.16 ± 0.34 | 2.19 ± 0.37 |
| Pancreas | 0.86 ± 0.16 | 0.34 ± 0.04 |
| Muscle | 0.39 ± 0.06 | 0.24 ± 0.01 |
| Tumor | 4.86 ±1.19 | 1.74 ± 0.90 * |
| Blood | 1.68 ± 0.33 | 1.30 ± 0.10 |
| Thyroid (% ID) | 0.01 ± 0.00 | 0.01 ± 0.00 |
| Tumor/Blood | 2.89 | 1.34 |
| Tumor/Muscle | 12.46 | 7.25 |
Radioactive accumulation in each organ or tissue (thyroid was evaluated as % ID) is expressed as % ID/g (mean ± SD for n = 5). The blocking studies were performed by a pre-injection of ZJ-43 (500 µg). * p < 0.05.