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. 2020 Nov 28;21(23):9078. doi: 10.3390/ijms21239078

Figure 2.

Figure 2

BBB leakage after stroke in mice: Akap12 KO mice or wild type (WT) mice were subjected to transient MCAO, and 3 days later, they were sacrificed for IgG staining. In WT mice, more IgG leakage was observed in the ipsilateral side compared to the contralateral side. In addition, KO mice showed exacerbated BBB damage, as assessed by IgG positive area. (a) Representative IgG staining images. (b) Quantitative results of IgG leakage in each brain section. Mean + SD of n = 9–10 per group. * p < 0.05 vs. WT for individual section. Two-way ANOVA followed by post-hoc Sidak’s multiple comparisons test. (c) Quantitative results of IgG leakage. Mean + SD of n = 9–10 per group. * p < 0.05 vs. WT. Mann-Whitney test.