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. 2020 Nov 28;21(23):9078. doi: 10.3390/ijms21239078

Figure 4.

Figure 4

Rho kinase and in vitro endothelial permeability: (a) In cultured cerebral endothelial cells, Akap12 siRNAs (siRNA#1 and siRNA#2) activated the Rho kinase pathway. (b–c) Rho kinase inhibitor Y-27632 (10 µM) ameliorated the morphology change and ZO-1/Claudin 5 disruption in AKAP12-deficient cells. Scale bar = 100 μm. (d) The increase of in vitro endothelial permeability in AKAP12-deficient cells was also relieved by Y-27632. Mean ± SD of n = 3. * p < 0.05. One-way ANOVA followed by post-hoc Tukey’s multiple comparisons test.