Table 2.
Cell proliferation rate and phosphorylation rate of ERK in the presence of peptide.
| Origin | Cell line | K-Ras mutation | KS-58 | KRpep-2d | ||
|---|---|---|---|---|---|---|
| Cell proliferation (%) | pERK (%) | Cell proliferation (%) | pERK (%) | |||
| Lung | A427 | G12D | 21.1 ± 5.5 | 26.0 ± 6.0 | 56.4 ± 9.4 | 38.5 ± 3.3 |
| A549 | G12S | 81.3 ± 1.5 | NT | 90.8 ± 7.8 | NT | |
| H1975 | WT | 92.7 ± 0.3 | NT | 98.0 ± 2.3 | NT | |
| Pancreas | PANC-1 | G12D | 50.1 ± 4.1 | 57.6 ± 7.6 | 80.4 ± 4.7 | 63.9 ± 4.8 |
| MIA PaCa-2 | G12C | 86.8 ± 2.3 | NT | 93.3 ± 3.5 | NT | |
| Capan-1 | G12V | 94.9 ± 2.2 | NT | 95.4 ± 4.4 | NT | |
Peptide concentration was 30 µM (n = 4, ± SEM). NT means not tested.