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. 2020 Dec 10;10:21612. doi: 10.1038/s41598-020-77884-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IL-6R peptide cleavage by Cathepsin S and ADAM17. (a) Sequences of the three peptides that were used in the experiments. IL-6R_PVQD corresponds to the wild-type sequence of the IL-6R, IL-6R-PVQA corresponds to an IL-6R containing the SNP rs2228145¹⁰ and IL-6R_PGQD corresponds to an IL-6R variants previously shown not to be cleaved by ADAM17²⁸. (b–d) Proteolysis of the three peptides by recombinant Cathepsin S (100 ng) and recombinant ADAM17 (100 ng) as measured via an increase in fluorescence over 120 min.