BBB |
Blood–brain barrier |
EGCG |
(−)-epigallocatechin gallate |
BDNF |
Brain-derived neurotrophic factor |
p-CREB |
Phosphor-(cyclic-AMP response element-binding protein) |
SSBs |
Single-strand breaks |
DSBs |
Double-strand breaks |
ROS |
Reactive oxygen species |
CNS |
Central nervous system |
SOD |
Superoxide dismutase |
GPX |
Glutathione peroxidase |
O2−
|
Superoxide anions |
OH−
|
Hydroxyl radicals |
H2O2
|
Hydrogen peroxide |
NF-κB |
Nuclear factor kappa-light-chain-enhancer of activated B cells |
SMAD |
Small mother against decapentaplegic |
IL-1 |
Interleukin-1 |
TNF-α |
Tumor necrosis factor α |
TGF-β |
Transforming growth factor β |
IFN-γ |
Interferon γ |
DAMPs |
Damage-associated molecular patterns |
PRRs |
Pattern recognition receptors |
TLRs |
Toll-like receptors |
HMGB1 |
High mobility group Box 1 |
HSPs |
Heat shock proteins |
NADPH |
Nicotinamide adenine dinucleotide phosphate |
MAPK |
Mitogen-activated protein kinases |
NHEJ |
Non-homologous end joining |
ATM |
A-T mutated |
ATR |
ATM and Rad3-related |
DNA-PK |
DNA-dependent protein kinase |
DRG |
Dorsal root ganglion |
CHOP |
C/EBP-homologous protein |
JNK |
Jun-N-terminal kinases |
P13K |
Phosphatidylinositol-3-kinase |
AKT |
Serine-threonin protein kinase |
GSK3β |
Glycogen synthase kinase 3 β |
NRF-2 |
Nuclear factor erythroid-2 related factor-2 |
DHF |
5, 7-dihydroxyflavone |
EGCG/AA NPs |
Nanoparticles of EGCG/ascorbic acid |
MDA |
Malondialdehyde |
GSH |
Glutathione |
CAT |
Catalase |
HO-1 |
Heme oxygenase-1 |
XO |
Xanthine oxidase |
LOX |
Lipoxygenase |
AO |
Aldehyde oxidase |
COX-2 |
Cyclooxygenase-2 |
AP-1 |
Activated protein-1 |