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. 2020 Dec 3;21(23):9226. doi: 10.3390/ijms21239226

Figure 2.

Figure 2

mRNA expression profiles of six representative DNA glycosylase genes in various carcinomas. mRNA expression profiles of UNG (A), SMUG1 (B), NTH1 (C), OGG1 (D), MPG (E) and NEIL3 (F). Data were extracted from the cBio Cancer Genomics Portal [140] by computing the expression of an individual gene in a tumor sample (z-score) relative to the gene’s expression in the normal sample. Samples with expression z-scores >2 or <−2 (indicated with dotted lines) in any queried gene are considered altered. mRNA expression levels are organized according to the copy-number level per gene: Deep deletion (dark blue) indicates a deep loss, possibly a homozygous deletion; shallow deletion (sky blue) indicates a shallow loss, possibly a heterozygous deletion; diploid (gray); gain (pink) indicates a low-level gain (a few additional copies, often broad); and amplification (red) indicates a high-level amplification (more copies, often focal). Cancer types: Bladder urothelial carcinoma (bladder; N = 404), colorectal adenocarcinoma (colorectal; N = 590), esophageal squamous cell carcinoma (esophageal; N = 94), hepatocellular carcinoma (liver; N = 358), invasive breast carcinoma (breast; N = 1068), non-small cell lung cancer (lung; N = 991), and prostate adenocarcinoma (prostate; N = 488).