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. 2020 Dec 3;21(23):9226. doi: 10.3390/ijms21239226

Figure 4.

Figure 4

Identification of specific inhibitors of human OGG1. (A) Crystal structure of human OGG1 crosslinked to 8-oxo-G containing dsDNA (PDB: 6W0M; [201]). (B) Crystal structure of human OGG1 bound to an active site-specific inhibitor, TH5487 (PDB 6RLW), represented in ball and sticks and as a transparent mesh. (C) Chemical structure of the highly specific OGG1 inhibitor selected by Tahara and colleagues [197], SU0268. (D) Chemical structure of the dual inhibitor, SU0383, which efficiently blocks both MTH1 and OGG1 activities [202].