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Model of regulation of balanced LPS and phospholipid biosynthesis: R-3-hydroxymyristoyl-ACP serves as a common metabolic precursor for the LpxC–dependent LPS biosynthesis and the FabZ-mediated phospholipid biosynthesis. LpxC stability is regulated by previously established FtsH/LapB and, from this study, via the negative regulation by LapC counteracting the LapB/FtsH pathway and also at high temperature by HslVU proteolysis of LpxC.
