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Truncation of the C-terminal periplasmic domain of LapC confers the sensitivity to the LpxC inhibitor CHIR090. Exponentially grown cultures of the wild type and its isogenic derivatives with point mutations in the lapC gene were adjusted to an OD595 of 0.1 and serially spot diluted at 30 °C on LA agar supplemented with or without varying concentrations of CHIR090 as indicated.
