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. 2020 Nov 26;21(23):8989. doi: 10.3390/ijms21238989

Figure 2.

Figure 2

Possible dimeric and oligomeric forms of RAGE. (A) RAGE dimers have been suggested to be required for signal transduction [104]; in this representation, all three extracellular domains and the transmembrane domain are involved in dimer formation. (B) Dimerization via the V domain only [112]. (C) Models for the inhibitory RAGE/sRAGE heterodimer [113]. (D) Ligand-induced RAGE homodimers [105]. (E) Dimerization via the V domain of RAGE between two different cells [114]. (F) Dimerization through a ligand bound to two C2 domains [115]. (G,H) Other oligomeric forms of RAGE have been proposed as well (tetramers and hexamers) [105].