RAGE |
Receptor for advanced glycation end product |
HMGB1 |
High Mobility Group Box 1 |
MSH |
Melanocyte stimulating hormone |
MC1-R |
Melanocortin 1 receptor |
CDKN2A |
Cyclin-dependent kinase inhibitor 2A |
MAPK |
Mitogen-activated protein kinase |
NRAS |
Neuroblastoma RAS viral oncogene homolog |
BRAF |
V-raf murine sarcoma viral oncogene homolog B1 |
PI3K |
Phosphatidylinositol-3 kinase |
mTOR |
Mammalian target of rapamycin |
NF1 |
Neurofibromatosis type1 |
ARID2 |
AT-rich interactive domain-containing protein 2 |
TP53 |
Tumor protein p53 |
PPP6C |
Serine/threonine-protein phosphatase 6 catalytic subunit |
DDX3X |
DEAD-box helicase 3 X-linked |
PTEN |
Phosphatase and tension homology |
RAC1 |
ras-related C3 botulinum toxin substrate 1 |
FBXW7 |
F-box/WD repeat-containing protein 7 |
SNX31 |
sorting nexin 31 |
PREX2 |
phosphatidylinositol-3,4,5- trisphosphate-dependent rac exchange factor 2 |
TACC1 |
transforming acidic coiled-coil-containing protein 1 |
KIT |
KIT tyrosine-protein kinase |
IDH1 |
isocitrate dehydrogenase1 |
RB1 |
retinoblastoma protein 1 |
SF3B1 |
splicing factor 3b subunit 1 |
CTNNB1 |
catenin (cadherin-associate protein) beta 1 |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
CDK4 |
cyclin-dependent kinase 4 |
RASA2 |
ras p21 protein activator 2 |
WT1 |
Wilms’ tumor suppressor gene 1 |
EZH2 |
enhancer of zeste homolog 2 |
STK19 |
serine/threonine-protein kinase 19 |
SSM |
superficial spreading melanoma |
AJCC |
American joint commission in cancer |
OS |
Overall survival |
DSS |
Disease-specific survival |
LDH |
Lactate dehydrogenase |
PD1L1 |
Programmed cell death receptor 1 ligand 1 |
PD-1 |
Programmed cell death receptor 1 |
IL-2 |
Interleukin 2 |
IFN-α |
Interferon alpha |
FDA |
Food and drug administration |
CTLA-4 |
Cytotoxic T lymphocyte antigen 4 |
MHC |
Major histocompatibility complex |
TM |
Transmembrane |
V |
Variable |
C1 |
Constant domain 1 |
C2 |
Constant domain 2 |
DAMPS |
Damage-associated molecular patterns |
AGE |
Advanced glycation end products |
TRPM-1 |
Transient receptor potential melastatin-1 |
SSSRs |
S100 soil sensor receptor |
EMMPRIN |
Extracellular matrix metalloproteinase inducer |
ALCAM |
Activated leukocyte cell adhesion molecule |
TLR-4 |
Toll-like receptor 4 |
NPTNβ |
Neuroplastin β |
MCAM |
Melanoma cells adhesion molecule |
NF-κB |
Nuclear factor kappa beta |
ROS |
Reactive oxygen species |
TPL2 |
Tumor progression locus 2 |
ETV4 |
ETS translocation variant 4 |
MMP-25 |
Matrix metalloproteinase 25 |
VEGF |
Vascular endothelial growth factor |
FGF |
Fibroblast growth factor |
CMM |
Cutaneous malignant melanoma |
MCP-1 |
Monocyte chemoattractant protein 1 |
Dia-1 |
Diaphanous-1 |
cdc 42 |
Cell division control protein 42 |
TIRAP |
Toll-like receptor 2/4 adaptors |
MyD88 |
Myeloid differentiation primary response 88 |
ERK |
Extracellular signal-related kinase |
JNK |
C-Jun N-terminal kinase |
TXNIP |
Thioredoxin interacting protein |
NLRP3 |
NLR family pyrin domain containing 3 |
JAK |
Janus kinase |
STAT |
Signal transducer and activator of transcription |
CREB |
Cyclin AMP response element-binding protein |
RSK2 |
Ribosomal S6 kinase 2 |
VCAM-1 |
Vascular cell adhesion molecule 1 |
ICAM-1 |
Intercellular adhesion molecule 1 |
TNF-α |
Tumor necrosis factor alpha |
NO |
Nitric oxide |
Tregs |
Regulatory T cells |