Skip to main content
. Author manuscript; available in PMC: 2020 Dec 11.
Published in final edited form as: Vitam Horm. 2019 Feb 8;110:17–45. doi: 10.1016/bs.vh.2019.01.002

Fig. 2.

Fig. 2

Regulation of hepcidin expression. Hepcidin expression involves iron sensing by hepatocytes. BMP6 and possibly BMP2 bind at BMP receptor, initiating a signaling cascade of SMAD1/5/8 phosphorylation which, couples with SMAD4 and translocates into the nucleus to initiate hepcidin transcription. As part of the inflammatory cascade, IL6 binds IL6 receptor, initiating a JAK/STAT signaling cascade of STAT3 phosphorylation which translocates into the nucleus and, in a SMAD-dependent manner, initiate hepcidin expression. BMP, bone morphogenic protein; BMPR, BMP receptor; Fe, iron; HFE, high iron Fe; HJV, hemojuvulin; IL6, interleukin 6; IL6R, IL6 receptor; JAK, janus kinase; sHJV, soluble HJV; SMAD, single mother against decapentaplegic; STAT, signaling transducer and activator of transcription; Tf, transferrin; TFs, transcription factors.