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. 2020 Dec 1;21(23):9163. doi: 10.3390/ijms21239163

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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In vivo, both FMC63 and 4G7 CAR T cells eliminated acute-lymphoblastic-leukemia-cell NALM-6. (A–C) NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice were injected intravenously (i.v.) with 5 × 10⁶ Luc-expressing NALM-6 cells. Next day, mice were administered with 1 × 10⁷ FMC63, 4G7, and FITC CAR T cells or phosphate buffered saline (PBS) control (i.v.). From day 5, tumor progression was observed via bioluminescence imaging. (A) Represents the luminescence image, and (B) indicates the luminescence value of each group. (C) Percentage survival was calculated.