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Polymeric NPs with several optimal design schemes. It was observed that the lipid core can be coated with polymeric materials, forming a lipid core and polymeric shell. In another case, polymeric materials can be condensed as a core template, and then a monolayer of lipids can be used to coat their surface, forming a face-like shape on the surface. Both the polymeric materials and lipid can be used to form the core template in the last case.
