Table 2.

SLNPs encapsulating different types of drugs for the treatment of lung cancer.

Drug	Composition	Preparation Techniques	Target	Ref.
Paclitaxel (PTX) and Erlotinib (ERL)	PTX- and ERL-co-loaded SLCN consisting of cores that accommodate both PTX and ERL and block copolymer coronae with PEGylated exterior.	Nanoprecipitation and sonication	Non-small cell lung carcinoma NSCLC (patients with activating-EGFR mutations)	[80]
Bberberine (BER) and Rapamycin (RAP)	Lactoferrin and HA were utilized to develop layer-by-layer lipid nanoparticles (NPs) for the dual delivery of BER and RAP to lung cancer.	Hot homogenization method	Adenocarcinomic human alveolar basal epithelial cells (HA targeted CD44 receptor)	[81]
Artemether (ART)	Oral anticancer drug ART-SLNs stabilized using MPEG2000- 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]-N-(Cyanine 5 (,DSPE) exhibited an anti-lipolytic effect	Pressure homogenization technique	Lung cancer	[82]
PTX	Inhaled drug delivery system. Paclitaxel-loaded SLN folate-grafted copolymer of PEG and N-((2-hydroxy-3-trimethylammonium)propyl) chitosan chloride coated liposomes. Surface modification was conducted to prolong the retention of PTX within the lungs	Carbodiimide-mediated coupling chemistry	Lung cancer (Folate receptors)	[83]
Gemcitabine (GmcH)	GmcH loaded mannosylated SLNs for improving drug uptake into the lung cancer cells	Emulsification and solvent	Lung cancer (Mannose receptor)	[84]
Erlotinib (ETB)	ETB-loaded SLN-based formulation of inhaled dry powder	Hot homogenization method followed by sonication	Non-small cell lung carcinoma (NSCLC)	[85]
PTX	PTX- and DNA-loaded NLC was prepared, and surface modification was done by transferring receptor -containing ligands.	Micro-emulsion technique.	Lung adenocarcinoma cell (Transferring receptor)	[86]
PTX and DOX	Combined delivery of PTX and DOX was prepared as a synergistic anti-tumor drug	Melted ultrasonic dispersion method	Non-small cell lung carcinoma (NSCLC)	[87]