Table 3.

Polymeric nanoparticles encapsulating different types of drugs for the treatment of lung cancer.

Drug	Composition	Preparation Technique	Target	Ref.
NU7441—radiosensitizer and Gemcitabine	A folate receptor targeting multifunctional, dual, drugs-loaded nanoparticles containing a poly(N-isopropylacrylamide)-carboxymethyl chitosan shell and a PLGA core to enhance localized chemo-radiotherapy	Standard emulsion method	Human dermal fibroblasts (HDFs) and Alveolar Type 1 epithelial cells	[96]
Erlotinib	Erlotinib-loaded core-shell-type lipid–polymer hybrid nanoparticles composed of polycaprolactone as the core and hydrogenated soy phosphatidylcholine/1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxyPEG2000) as the shell	Single-step sonication method	Non-small cell lung cancer (NSCLC).	[97]
Cisplatin (CDDP) and Metformin	Co-encapsulation of CDDP and metformin into single self-assembled core-membrane NPs. CDDP was first conjugated to PGA to form PGA-CDDP, which was electrostatically complexed with the cationic polymer metformin (polymet) and then coated with PEGylatedcationic liposomes to form the final core–membrane structure.		Non-small cell lung cancer (NSCLC).	[98]
Gemcitabine (Gem)	Silk fibroin nanoparticles (SFNPs) used for the systemic delivery of gemcitabine (Gem) For targeting the tumorigenic lung tissue, SP5-52 peptide was conjugated to Gem-loaded SFNPs.	Electrospraying and desolvation method	Animal lung cancer	[99]
paclitaxel (PTX)	PTX-loaded polymeric nanoparticles (PTX-NPs) combined with circadian chronomodulated chemotherapy The polymer nanoparticles were prepared from two amphiphilic three-block copolymers: poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone)	Thin film dispersion technique	Non-small cell lung cancer (NSCLC).	[100]