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. 2020 Dec 1;25(23):5662. doi: 10.3390/molecules25235662

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Structures of “new” fluoroquinolones and non-fluoroquinolone topoisomerase inhibitors discussed in the text. Gepotidacin and Zoliflodacin (Novel Bacterial Topoisomerase Inhibitors) are both in phase III clinical trials. Thiophene 2: N-(2-amino-1-phenylethyl)-5-(2-chlorophenyl)-2-methylthiophene-3-carboxamide, Imidazopyrazinone t1: 7-((3~[S])-3-azanylpyrrolidin-1-yl)-.5-cyclopropyl-8-fluoranyl-imidazo (1,2-a)quinoxalin-4-one and Quinazolinedione UING5-207: 3-Amino-1-cyclopropyl-7-((3R)-3-ethyl-1-pyrrolidinyl)-6-fluoro-8-methoxy-2,4(1H,3H)-quinazolinedione.