Table 5.

Patents relating to the use of drone brood as an ingredient in supplements in the prevention/treatment of various health problems [https://worldwide.espacenet.com/].

No	Title	Applicants [Country]	Publication Number	Earliest Priority/Publication	Description
1	Insect protein-containing preparation and method for treating androgen deficiency in women	PARAFARM [RU]	UA140992U	2016-03-10/2020-03-25	The preparation for androgen deficiency in women contains a homogenate of brood and can be produced in the form of tablets, capsules or powder. The method of treating androgen deficiency in a woman is to administer the preparation in an amount of 10 mg to 600 mg per day.
2	Method of treating androgen deficiency in women	Kurkus’ N.V. [RU] and 15 co-authors	US20170065646A1	2017-03-09/2018-05-22	The invention relates to biologically active food supplements and is intended for treating androgen deficiency in women and for preventive action against the states associated with osteoporosis. Powdered calcium carbonate mix with drone brood lyophilizate (9:1) in form of tablets. One capsule administration 3 times a day for the month separately from meals.
3	Method of producing bio preparation with nootropic activity	Budget Institution of Higher Vocational Education of the State Fed [RU]	RU2609872C1	2015-11-25/2017-02-06	The bio preparation of homogenizing bee brood drone larvae in cooled isotonic NaCl solution, boiling male bee brood larvae homogenate in order to denature proteins, removing sediment on a paper filter and cleaning with a membrane. The described method allows to obtain a peptide preparation with nootropic effect.
4	Method of treating osteoarthrosis	PARAFARM [RU]	RU2593018C1	2015-10-28/2016-07-27	The invention “Osteomed forte” is using for the invention enables the reduction of the pain syndrome and motor dysfunctions in the joints of the hands and feet. Containing 20–1000 mg of drone brood in combination with vit. D in the amount of 100-50,000 IU, a calcium compound 40–1000 mg. Osteomed forte is taken in the amount of 1 tablet in the morning and evening, with 3-month treatments 3 times a year.
5	Composition for preventing and healing compromised bone and a method of making same	Andreeva E. S. [RU] and 17 co-authors	US2016339063A1	2009-11-30/2016-11-24	The biologically active additive composition comprises the selected pharmacologically active calcium compound in an amount of 16.67–93.75 wt.% and drone brood in an amount of 6.25–83.33% by weight. The application prevents and treats osteoporosis, bone fractures and cavities, arthritis, arthrosis, periodontitis, with a significantly reduced risk of calcium deposition in soft tissues.
6	Application of adsorbed drone brood homogenate and group D vitamins and/or their active metabolites for prevention and treatment of acute respiratory diseases and flu	PARAFARM [RU]	RU2013130302A RU2564111C2 RU2564111C9	2013-07-03/2015-01-08	The proposed biologically active additive comprises adsorbed drone brood homogenate, the daily dose thereof lying between 75 mg and 500 mg, and vitamin or vitamins of group D and/or their active metabolites, a daily dose thereof between 25 IE and 50,000 IE.
7	Biologically active food additive for the prophylaxis of erectile dysfunction in men	PARAFARM [RU]	EP2687107A2	2012-10-04/2014-01-22	The product contains L-arginine and also drone brood with the following components: 50–96.2% by weight of L-arginine and 3.8–50% by weight of drone brood.
8	Coffee drink	PARAFARM [RU]	CA2840708A1 CA2840708C	2011-07-05/2013-01-10	Intended for prophylaxis and therapeutic prophylaxis in conditions associated with fatigue, and is in the form of a coffee or other drink and consists of: 1 part drone brood, 3–9 parts glucose and/or fructose, and 1–100 parts fillers (coffee or other drink in powder form).
9	Preparation and method for the prophylaxis and treatment of atypical osteoporosis	PARAFARM [RU]	US2015224150A1 US9827273B2	2012-04-19/2013-10-24	The preparation consists of 10 mg to 1000 mg daily of drone brood and 50 IU to 100,000 IU daily of vitamin D or vitamins of this group and/or their active metabolites can be supplied in a powder, tablet or capsule.
10	Medication for treatment and prevention urogenital system diseases in males	PARAFARM [RU]	RU2423142C1	2009-12-02/2011-06-09	Preparation contains drone brood with the following weight ratio of components: drone brood (powder) 25–75% naked licorice root (powder) 75–25%. Taking the drug stimulates the work of the glands, normalizes the reproductive system in men, has anti-inflammatory and anesthetic properties, normalizes urination and restores sexual functions.