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Overview of compounds sofosbuvir (yellow, PDB-ID: 4WTG), beclabuvir (green, PDB-ID: 4NLD), radalbuvir (magenta, PDB-ID: 4EO6), and filibuvir (cyan, PDB-ID: 3FRZ) co-crystallized into the different binding sites of the RdRp of HCV. Residues involved in polar interactions are represented as sticks and are labeled. Polar contacts are highlighted by black dashed lines.
