Table 2.
Size and zeta potential of liposome formulations after production, as determined by photon correlation spectroscopy (PCS).
| LP-P (PC/CH) | LP-DCP (PC/CH/DCP) | LP-DDAC (PC/CH/DDAC) | LP-DEBDA (PC/CH/DEBDA) | LP-SA (PC/CH/SA) | |
|---|---|---|---|---|---|
| Z ave (nm) 1 | 191.5 ± 1.7 | 180.1 ± 3.7 | 197.0 ± 2.1 | 180.1 ± 1.0 | 205.7 ± 1.6 |
| P.I. 2 | 0.11 ± 0.07 | 0.36 ± 0.1 | 0.20 ± 0.08 | 0.36 ± 0.06 | 0.23 ± 0.05 |
| ζ Potential (mV) 3 | −28.4 ± 0.4 | −67.4 ± 2.6 | +90.6 ± 0.3 | +92.3 ± 2.0 | +63.1 ± 0.9 |
1 Zeta average diameter (mean size). 2 Polydispersity index. 3 Zeta Potential. Data are the mean of 5 independent determinations on different batches of the same dispersion ± standard deviation.