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EC50, CC50, and Selectivity Index (SI) values for a selection of dipeptidyl glutaminyl FMKs in SARS-CoV-infected Vero and CaCo2 cultures [4].
| |||||||
|---|---|---|---|---|---|---|---|
| EC50 (µM) | CC50 (µM) | SI | |||||
| Vero | CaCo2 | Vero | |||||
| Entry | Compound | R | FFM1 | 6109 | FFM1 | ||
| 1 | 80a |
|
3.6 ± 1.3 | 2.5 ± 0.4 | 2.4 ± 0.56 | >100 | >40 |
| 2 | 80b |
|
8.9 ± 2.9 | 5.3 ± 1.7 | 8.8 ± 2.5 | >100 | >18 |
| 3 | 80c |
|
6.2 ± 1.9 | 6.6 ± 3.0 | 12.6 ± 4.1 | >100 | >15 |
