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. 2020 Dec 3;21(23):9211. doi: 10.3390/ijms21239211

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gene Set Enrichment Analysis (GSEA) performed by WEB-based Gene SeT AnaLysis Toolkit (WebGestalt). Significantly (FDR < 0.05, p< 0.001) enriched Gene Ontology (GO) terms among down- and up-regulated differentially expressed genes (DEGs) ranked by increasing log2 fold-change (FC), considering the effect of eCO₂ in CL153 (left) and Icatu (right). Gene Ontology (GO) terms are grouped by the main category – Biological Process (GO:BP), Molecular Function (GO:MF), and Cellular Component (GO:CC). Counts indicate the number of DEGs annotated with each term/pathway and dots are colored by ascending normalized enrichment score (NES).