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. 2020 Dec 3;25(23):5693. doi: 10.3390/molecules25235693

Table 1.

In vitro ERK 2 and PI3Kα inhibitory activities of compounds 16a~16d.

graphic file with name molecules-25-05693-i001.jpg

Entry R1 R2 ERK2 Inhibition% (1 μM) PI3Kα Inhibition% (1 μM)
16a graphic file with name molecules-25-05693-i002.jpg graphic file with name molecules-25-05693-i003.jpg 98.3 8.7
16b graphic file with name molecules-25-05693-i004.jpg graphic file with name molecules-25-05693-i005.jpg 84.8 27.4
16c graphic file with name molecules-25-05693-i006.jpg graphic file with name molecules-25-05693-i007.jpg 97.2 1.8
16d graphic file with name molecules-25-05693-i008.jpg graphic file with name molecules-25-05693-i009.jpg 79.5 4.0
BVD-525 97.7 ND
BYL-719 ND 96.7

ND = not determined.