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% Reduction of plaques and CC50 of acyclovir (ACV) before and after addition of F5 against HS-1 virus, each point represents the mean ± SD (n = 3). Abbreviation: F5, the optimized Curcumin-loaded proniosomal formula; ACV, Acyclovir; HS-1, Herpes simplex type I virus; CC50, the half-maximal cytotoxic concentration.
