Table 4.

ANOVA for the 3² factorial design of Curcumin-loaded proniosomes.

Depndent Variable	Source	SS	DF	MS	F-Value	p-Value
Y1	Model	1053.93	4	263.48	29.84	0.0031
	X1	312.89	2	156.45	17.72	0.0103
	X2	471.03	2	370.52	41.97	0.0021
Y2	Model	2724.45	4	681.11	55.09	0.0009
	X1	235.90	2	117.95	9.54	0.0300
	X2	2488.55	2	1244.28	100.64	0.0004

Notes: Y1: EE (%), Y2: Q_12h (%), ratio of surfactant to CHOL (X1), the surfactant type (X2), p-value less than 0.05 shows that the model terms are significant. Abbreviation: SS, sum of squares; DF, degree of freedom; MS, mean of squares.