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. 2020 Nov 27;25(23):5571. doi: 10.3390/molecules25235571

Figure 5.

Figure 5

Cardiac I/R injury leads to dynamic changes in SUMO2 proteome. (A) Alteration of SUMO2/3 target proteins upon cardiac I/R injury in the mouse heart. The heat map displays relative changes in SUMO2/3 targets during I/R when compared to sham control. SUMO2/3 targets were defined after imputation as follows, difference SUMO2/3 IP versus IgG IP log2 ratio > 0.58 (difference is higher than 1.5×) and -log 10 p value > 1.3 (p < 0.05). (B) Heatmap of a sub-group of SUMO2/3 target proteins playing a role in the regulation of gene expression in the mouse heart upon I/R injury. (C) Heatmap of a sub-group of SUMO2/3 target proteins belonging to the protein quality control machinery (UPS, SUMO system, chaperones) in the mouse heart upon I/R injury. (D) Bar diagrams of significantly changed SUMO2/3 targets, when experimental conditions (Isch, I/R1, I/R24) are compared to Sham. Data are expressed in mean ± SEM, asterisks show significant differences compared to Sham (n = 3, * p < 0.05, ** p < 0.01, *** p < 0.001).