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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Adv Cancer Res. 2020 May 4;148:201–232. doi: 10.1016/bs.acr.2020.03.001

Table 1. A sampling of literature with references to functional PGCC using varied terminology.

The presence of polynuclear cells with pluripotent and malignant potential have been reported for many years, yet a cohesive field of shared terminology is only beginning to appear. These references represent some of the papers that form a large but sporadic body of work that underlies the emerging PGCC field.

Term in use Primarily used by Site (reference)
PGCC: Polyploid Giant Cancer Cell* Cell biologists Breast (K. Liu et al., 2019; Lopez-Sanchez et al., 2014; Sirois et al., 2019; Wang et al., 2019; Xuan et al., 2018)
Colorectal (Arun et al., 2019; Fei, Li, et al., 2019; Fei, Zhang, et al., 2019; D. Zhang et al., 2017; S. Zhang, Zhang, Yang, & Zhang, 2016)
Glioma (Qu, Zhang, Rong, He, & Zhang, 2013)
Lung (Glassmann et al., 2018; White-Gilbertson et al., 2019)
Ovarian (K. Liu et al., 2019; Lv et al., 2014; Niu et al., 2017; Niu et al., 2016; Rohnalter et al., 2015; Wang et al., 2019; L. Zhang et al., 2014; S. Zhang, Mercado-Uribe, Hanash, et al., 2013; S. Zhang, Mercado-Uribe, & Liu, 2013; S. Zhang, Mercado-Uribe, et al., 2016)
Prostate (Lin et al., 2019; White-Gilbertson et al., 2019)
ETC: Endopolyploidy Tumor Cells polyploid/polyploidizing/depolyploidizing Cell biologists Breast (Puig et al., 2008)
Colon (Ianzini et al., 2009; Puig et al., 2008)
Cervical (Erenpreisa et al., 2009; Erenpreisa et al., 2008; Erenpreisa et al., 2011; Ianzini et al., 2009; Schwarz-Finsterle et al., 2013)
Lung (Rohnalter et al., 2015)
Lymphoma (Erenpreisa et al., 2009; Erenpreisa et al., 2008; Erenpreisa et al., 2011; Kalejs et al., 2006)
Ovarian (Rohnalter et al., 2015)
MN/PG: MultiNucleate/Polyploid Giant
MNGC: MultiNucleated and Giant Cells
MOGC: MOnonucleated Giant Cells
MP: Multinucleated Polyploid Giant MP: Giant Multinucleated Polyploid
MGC: Multinucleated Giant Cells
GCC: Giant Cancer Cells
Cell biologists Or pathologists Cervical (Erenpreisa et al., 2005; Sundaram et al., 2004)
Colon (Mirzayans, Andrais, Scott, et al., 2017)
Glioblastoma (Kaur et al., 2019; Kaur et al., 2015; Ogawa et al., 2019; Oh et al., 2016)
Lymphoma (Erenpreisa et al., 2005)
Nasopharyngeal (Jiang et al., 2015)
Neuroblastoma (Sundaram et al., 2004)
Pancreas (Hasegawa et al., 2017)
Prostate (Mittal et al., 2017; L. Zhang et al., 2015)
Renal (Faragalla, Al-Haddad, Stewart, & Yousef, 2010; Sundaram et al., 2004)
Salivary gland (Daneshbod, Khademi, Kadivar, & Ganjei-Azar, 2008) Thyroid (X. Zhang et al., 2018)
Monster Monstrocellular Pathologists Brain (Gherardi et al., 1986; Palma, Celli, Maleci, Di Lorenzo, & Cantore, 1989)
Skin (Boyd, Wu, & Shyr, 2005; Defty, Segen, Carter, Ahmed, & Carr, 2011; Hawryluk, Baran, Gerami, & Sepehr, 2013; Pouryazdanparast, Newman, Mafee, Guitart, & Gerami, 2009)
OGC: Osteoclast-like Giant Cells
Osteoclast-like
Pathologists Breast (Albawardi, Awwad, & Almarzooqi, 2014; Pena-Jaimes et al., 2018)
Bowel sarcoma (Friedrichs et al., 2005)
Pancreas (Hoorens, Prenzel, Lemoine, & Kloppel, 1998; Jo, 2014; Luchini et al., 2018; Matsubayashi et al., 2019; Sekulic et al., 2016)
Skin (Chung, Wolpowitz, Scott, Gilmore, & Bhawan, 2016; Wasserman et al., 2015)
Thyroid (Gaumann et al., 2001)
Pleomorphic
Anaplastic
Syncytial-type
Pathologists Carcinoma, NOS, (Caruso et al., 2011)
Prostate (Alharbi et al., 2018)
Pancreas (Bergmann et al., 2010)
Renal (Williamson et al., 2014)
Thyroid (Deeken-Draisey, Yang, Gao, & Alexiev, 2018; Gaumann et al., 2001)
*

term of growing consensus