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. 2020 Dec 2;21(23):9193. doi: 10.3390/ijms21239193

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The structures of two major inter-alpha inhibitor proteins (IAIPs) endogenously present in serum, inter-alpha inhibitor (IaI; 250 kDa) and pre-alpha inhibitor (PaI; 125 kDa). IAIPs contain a glycosaminoglycan (GAG) backbone of chondroitin sulfate disaccharide repeats. Protein components, termed heavy chains, are connected to the GAG backbone. The light chain (LC; ~25 kDa) is present on both IaI and PaI. Heavy chains (HC; ~100 kDa) differ between IAIPs, with heavy chain 1 (HC1) and heavy chain 2 (HC2) on IaI and heavy chain 3 (HC3) on PaI.