TABLE 1.
Characteristics of gastric cancer patients undergoing curative-intent gastrectomy after preoperative chemotherapy and CXRT stratified according to TRG.
| n (%) | ||||||
|---|---|---|---|---|---|---|
| Characteristic | All (n = 247) | TRG | ||||
| 0 (n = 52) | 1 (n = 49) | 2 (n = 98) | 3 (n = 48) | P value | ||
| Age | 0.205 | |||||
| <65 years | 159 (64.4) | 28 (53.8) | 33 (67.3) | 69 (70.4) | 29 (60.4) | |
| ≥65 years | 88 (35.6) | 24 (46.2) | 16 (32.7) | 29 (29.6) | 19 (39.6) | |
| Sex | 0.041 | |||||
| Male | 147 (59.5) | 37 (71.2) | 34 (69.4) | 51 (52.0) | 25 (52.1) | |
| Female | 100 (40.5) | 15 (28.9) | 15 (30.6) | 47 (48.0) | 23 (47.9) | |
| Race/ethnicity | 0.543 | |||||
| White | 137 (55.5) | 31 (59.6) | 30 (61.2) | 53 (54.1) | 23 (47.9) | |
| Black | 22 (8.9) | 3 (5.8) | 5 (10.2) | 9 (9.2) | 5 (10.4) | |
| Asian | 61 (24.7) | 13 (25.0) | 10 (20.4) | 21 (21.4) | 17 (35.4) | |
| Hispanic/Latino | 27 (10.9) | 5 (9.6) | 4 (8.2) | 15 (15.3) | 3 (6.3) | |
| Tumor histology | 0.710 | |||||
| Moderately differentiated | 52 (21.1) | 13 (25.0) | 9 (18.4) | 22 (22.5) | 8 (16.7) | |
| Poorly differentiated | 175 (70.9) | 33 (63.5) | 35 (71.4) | 71 (72.5) | 36 (75.0) | |
| Unknown | 20 (8.1) | 6 (11.5) | 5 (10.2) | 5 (5.1) | 4 (8.3) | |
| Signet ring cell features | <0.001 | |||||
| No | 126 (51.0) | 42 (80.8) | 25 (51.0) | 43 (43.9) | 16 (33.3) | |
| Yes | 121 (49.0) | 10 (19.2) | 24 (49.0) | 55 (56.1) | 32 (66.7) | |
| Linitis plastica | 0.150 | |||||
| No | 223 (90.3) | 50 (96.2) | 43 (87.8) | 90 (91.8) | 40 (83.3) | |
| Yes/suspected | 24 (9.7) | 2 (3.9) | 6 (12.2) | 8 (8.2) | 8 (16.7) | |
| Tumor location | 0.030 | |||||
| Gastroesophageal junction | 67 (27.1) | 16 (30.8) | 19 (38.8) | 26 (26.5) | 6 (12.5) | |
| Cardia/fundus | 18 (7.3) | 4 (7.7) | 3 (6.1) | 9 (9.2) | 2 (4.2) | |
| Body | 101 (40.9) | 18 (34.6) | 14 (28.6) | 43 (43.9) | 26 (54.2) | |
| Distal | 50 (20.2) | 14 (26.9) | 9 (18.4) | 18 (18.4) | 9 (18.8) | |
| Total | 11 (4.5) | 0 (0.0) | 4 (8.2) | 2 (2.0) | 5 (10.4) | |
| Margin status | 0.213a | |||||
| R0 | 229 (92.7) | 52 (100.0) | 44 (89.8) | 92 (93.9) | 41 (85.4) | |
| R1 | 18 (7.3) | 0 (0.0) | 5 (10.2) | 6 (6.1) | 7 (14.6) | |
| Postoperative chemotherapy | 0.148 | |||||
| No | 238 (96.4) | 51 (98.1) | 48 (98.0) | 91 (92.9) | 48 (100.0) | |
| Yes | 9 (3.6) | 1 (1.9) | 1 (2.0) | 7 (7.1) | 0 (0.0) | |
| Organ resection | 0.129 | |||||
| No | 207 (83.8) | 44 (84.6) | 45 (91.8) | 76 (77.6) | 42 (87.5) | |
| Yes | 40 (16.2) | 8 (15.4) | 4 (8.2) | 22 (22.5) | 6 (12.5) | |
| Extent of lymph node dissection | 0.442 | |||||
| D0/D1 | 28 (11.3) | 8 (15.4) | 7 (14.3) | 6 (6.1) | 7 (14.6) | |
| D1+/D2 | 218 (88.3) | 44 (84.6) | 42 (85.7) | 91 (92.9) | 41 (85.4) | |
| Unknown | 1 (0.4) | 0 (0.0) | 0 (0.0) | 1 (1.0) | 0 (0.0) | |
| Number of lymph nodes examined | 0.026 | |||||
| <16 | 68 (27.5) | 17 (32.7) | 19 (38.8) | 17 (17.4) | 15 (31.3) | |
| ≥16 | 179 (72.5) | 35 (67.3) | 30 (61.2) | 81 (82.7) | 33 (68.8) | |
| cT category | 0.714 | |||||
| 1 | 1 (0.4) | 0 (0.0) | 0 (0.0) | 1 (1.0) | 0 (0.0) | |
| 2 | 30 (12.2) | 5 (9.6) | 9 (18.4) | 9 (9.2) | 7 (14.6 | |
| 3/4a | 193 (78.1) | 41 (78.9) | 38 (77.6 | 78 (79.6) | 36 (75.0) | |
| 4b | 23 (9.3) | 6 (11.5) | 2 (4.1) | 10 (10.2) | 5 (10.4) | |
| cN status | 0.492 | |||||
| Negative | 106 (42.9) | 19 (36.5) | 23 (46.9) | 46 (46.9) | 18 (37.5) | |
| Positive | 141 (57.1) | 33 (63.5) | 26 (53.1) | 52 (53.1) | 30 (62.5) | |
| ypT category | <0.001 | |||||
| 0 | 52 (21.1) | 52 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| 1a/1b | 40 (16.2) | 0 (0.0) | 18 (36.7) | 19 (19.4) | 3 (6.3) | |
| 2 | 48 (19.4) | 0 (0.0) | 14 (28.6) | 24 (24.5) | 10 (20.8) | |
| 3 | 85 (34.4) | 0 (0.0) | 16 (32.7) | 44 (44.9) | 25 (52.1) | |
| 4a/4b | 22 (8.9) | 0 (0.0) | 1 (2.0) | 11 (11.2) | 10 (20.8) | |
| ypN status | <0.001 | |||||
| ypN- | 161 (65.2) | 46 (88.5) | 34 (69.4) | 63 (64.3) | 18 (37.5) | |
| ypN+ | 86 (34.8) | 6 (11.5) | 15 (30.6) | 35 (35.7) | 30 (62.5) | |
| LR | 0.892 | |||||
| No | 232 (93.9) | 52 (100.0) | 46 (93.9) | 90 (91.8) | 44 (91.7) | |
| Yes | 15 (6.1) | 0 (0.0) | 3 (6.1) | 8 (8.2) | 4 (8.3) | |
| DR | 0.057 | |||||
| No | 168 (68.0) | 42 (80.8) | 35 (71.4) | 64 (65.3) | 27 (56.3) | |
| Yes | 79 (32.0) | 10 (19.2) | 14 (28.6) | 34 (34.7) | 21 (43.8) | |
| Vital status | 0.418 | |||||
| Alive | 131 (53.0) | 27 (51.9) | 24 (49.0) | 58 (59.2) | 22 (45.8) | |
| Dead | 116 (47.0) | 25 (48.1) | 25 (51.0) | 40 (40.8) | 26 (54.2) | |
| Type of resection | 0.233 | |||||
| Total gastrectomy | 140 (56.7) | 26 (50.0) | 31 (63.3) | 52 (53.1) | 31 (64.6) | |
| Subtotal gastrectomy | 93 (37.7) | 22 (42.3) | 13 (26.5) | 42 (42.9) | 16 (33.3) | |
| Proximal gastrectomy | 14 (5.7) | 4 (7.7) | 5 (10.2) | 4 (4.1) | 1 (2.1) | |