TABLE 2.

Univariable and multivariable Cox regression analysis of factors associated with LR in gastric cancer patients treated with preoperative chemotherapy and CXRT.

Univariable
Variable	HR (95% CI)	P value
TRG		0.895
0 (ref)	ref
1	-
2	-
3	-
ypN status (ypN+ vs. ypN-)	1.75 (0.62–4.92)	0.291
ypT category		0.074
0	-
1 (ref)	ref
2	2.39 (0.25–22.9)	0.451
3	4.08 (0.50–33.16)	0.189
4a/b	14.38 (1.58–130.92)	0.018
Age at diagnosis (≥65 vs. <65 years)	1.24 (0.44–3.49)	0.679
Sex (female vs. male)	0.93 (0.33–2.62)	0.895
Race/ethnicity		0.846
White (ref)	ref
Black	1.38 (0.30–6.37)	0.683
Asian	0.73 (0.20–2.70)	0.637
Hispanic	0.54 (0.07–4.29)	0.563
Tumor location		0.257
Gastroesophageal junction	ref
Cardia/fundus	2.21 (0.37–13.25)	0.385
Body	0.84 (0.19–3.77)	0.824
Antrum	1.75 (0.39–7.83)	0.463
Total	5.25 (0.87–31.58)	0.070
Tumor histology		0.987
Moderately differentiated	ref
Poorly differentiated	1.11 (0.31–3.94)	0.872
Unknown	-
Signet ring cell features (yes vs. no)	3.03 (0.96–9.51)	0.058
Linitis plastica (yes/suspected vs. no)	1.97 (0.44–8.79)	0.373
Concomitant organ resection	2.08 (0.66–6.53)	0.210
Adjuvant therapy (yes vs. no)	1.94 (0.26–14.73)	0.523
Number of lymph nodes examined <16	1.59 (0.45–5.67)	0.468
Extent of lymph node dissection		0.880
D0/D1	ref
D1+/D2	0.68 (0.15–3.02)	0.613
Unknown	-
R1 resection	22.12 (7.78–62.90)	<0.001
ypM1 status	6.65 (0.86–51.16)	0.069
Type of resection		0.503
Total gastrectomy	ref
Subtotal gastrectomy	0.85 (0.28–2.60)
Proximal gastrectomy	2.23 (0.47–10.52)
Multivariable
Variable	HR (95% CI)	P value
TRG		0.972
0 (ref)	Ref
1	>99.99
2	>99.99
3	>99.99
ypN status (ypN+ vs. ypN-)	0.75 (0.15–3.64)	0.721
Linitis plastica (yes/suspected vs. no)	1.31 (0.45–3.83)	0.625
R1 resection	17.85 (6.06–52.57)	<0.001